I have 2 Overlander 2200mah 2S 45C running in rotation. It copes really well with then, I get some great performance out of them. And top end, full pace is not difficult to handle.
I did have to Dremel off the outer ends of the battery holders to fit the slight extra width of the packs, but as there's a lip to the base the strap holds them very securely.
I've not tried 3S, so couldn't say how it handles but wouldn't fancy trying to cope with that. Can't vouch for how the other components would cope either.